This medicine makes me feel worse than my high blood pressure and it doesn't bring it down enough for me to feel like this. Dizzy, light-headed, constipated, headache, and just an overall feeling of yuck. I have been taking 200mg 2x daily for the past month and a half. I am 2 months postpartum and was diagnosed with preeclampsia at the third trimester so when it didn't come down after delivery my ob put me on this as it was safe for breastfeeding. Thus, labetalol is able to reduce heart rate during exercise while maintaining cardiac output by the increase in stroke volume. Westfall, David P 2004. cyclophosphamide code
Should side effects principally nausea or dizziness occur with these doses administered twice daily, the same total daily dose administered three times daily may improve tolerability and facilitate further titration. Titration increments should not exceed 200 mg twice daily. When a diuretic is added, an additive antihypertensive effect can be expected. In some cases this may necessitate a labetalol HCl dosage adjustment. As with most antihypertensive drugs, optimal dosages of labetalol HCl tablets are usually lower in patients also receiving a diuretic. When transferring patients from other antihypertensive drugs, labetalol HCl tablets should be introduced as recommended and the dosage of the existing therapy progressively decreased.
Labetalol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation blood flow through arteries and veins. Dizziness and tiredness may occur. Scalp tingling may also occur as your body adjusts to the medication. Decreased sexual ability has been reported rarely. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Beta-blockers, even those with apparent cardioselectivity, should not be used in patients with a history of obstructive airway disease, including asthma.
The blood pressure should be monitored during and after completion of the infusion or intravenous injection. Rapid or excessive falls in either systolic or diastolic blood pressure during intravenous treatment should be avoided. In patients with excessive systolic hypertension, the decrease in systolic pressure should be used as an indicator of effectiveness in addition to the response of the diastolic pressure. Exam Zone 1 January 2009. Hepatic Injury: Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with therapy with labetalol therapy. The hepatic injury is usually reversible, but hepatic necrosis and death have been reported. Injury has occurred after both short- and long-term treatment and may be slowly progressive despite minimal symptomatology. Similar hepatic events have been reported with a related research compound, dilevalol HCl, including two deaths. Dilevalol HCl is one of the four isomers of labetalol HCl. Thus, for patients taking labetalol, periodic determination of suitable hepatic laboratory tests would be appropriate.
How should I take labetalol Trandate? Prescribers should be cautious in the use of labetalol for nursing mothers. Since the half-life of this drug is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period; the infusion should be continued until a satisfactory response is obtained and should then be stopped and the oral formulation should be started. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. If your adrenal tumor grows large, it can press against other organs. You may feel a pain in your stomach or back. Or you could feel pressure or fullness soon after you eat. You may even notice a lump. On the other hand, if your tumor is small, you might not feel like anything's wrong. Subsequent oral dosing with labetalol hydrochloride tablets should begin when it has been established that the supine diastolic blood pressure has begun to rise. Girls with too much estrogen can start their periods or start growing breasts at a very young age. Boys can make too much of that hormone also, and grow breasts. Where can I get more information? Lund-Johansen, P. 1988-01-01. "Hemodynamic effects of beta-blocking compounds possessing vasodilating activity: a review of labetalol, prizidilol, and dilevalol". Journal of Cardiovascular Pharmacology. The presence of labetalol metabolites in the urine may result in falsely elevated levels of urinary catecholamines, metanephrine, normetanephrine, and vanillylmandelic acid when measured by fluorimetric or photometric methods. Crazy how medications can affect people in so many different ways, but it's not proper for people to warn others against using. This drug can help some people very much. I was on stupid amounts of Clonidine and replacing it with this drug has definitely made a difference for the better. F. Protect from freezing. Single oral doses of labetalol HCl administered to patients with coronary artery disease had no significant effect on sinus rate, intraventricular conduction, or QRS duration. The atrioventricular A-V conduction time was modestly prolonged in two of seven patients. In another study, IV labetalol HCl slightly prolonged A-V nodal conduction time and atrial effective refractory period with only small changes in heart rate. The effects on A-V nodal refractoriness were inconsistent. Either of two methods of administration of Labetalol hydrochloride injection may be used: a repeated intravenous injection, or b slow continuous infusion.
In women, repair may be recommended for smaller aneurysms. Transient increases in blood urea nitrogen and serum creatinine levels occurred in 8 of 100 patients; these were associated with drops in blood pressure, generally in patients with prior renal insufficiency. It has two asymmetric centers and therefore exists as a molecular complex of two diastereoisomeric pairs. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. In patients with latent cardiac insufficiency, continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. Whether you need the repaired. Nicotine and may harm an unborn baby. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. eskazole
Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with labetalol therapy. The hepatic injury is usually reversible, but hepatic necrosis and death have been reported. Injury has occurred after both short- and long-term treatment and may be slowly progressive despite minimal symptomatology. Similar hepatic events have been reported with a related research compound, dilevalol HCl, including two deaths. Dilevalol HCl is one of the four isomers of labetalol HCl. Thus, for patients taking labetalol, periodic determination of suitable hepatic laboratory tests would be appropriate. If cardiac failure continues, despite adequate digitalization and diuretic, therapy with labetalol HCl tablets should be withdrawn gradually, if possible. Dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Since the full antihypertensive effect of labetalol is usually seen within the first 1 to 3 hours of the initial dose or dose increment, the assurance of a lack of an exaggerated hypotensive response can be clinically established in the office setting. The antihypertensive effects of continued dosing can be measured at subsequent visits, approximately 12 hours after a dose, to determine whether further titration is necessary. The capacity of labetalol HCl to block alpha receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold water “cold-pressor test”. Labetalol HCl's beta 1-receptor blockade in man was demonstrated by a small decrease in the resting heart rate, attenuation of tachycardia produced by isoproterenol or exercise, and by attenuation of the reflex tachycardia to the hypotension produced by amyl nitrite. Beta 2-receptor blockade was demonstrated by inhibition of the isoproterenol-induced fall in diastolic blood pressure. Both the alpha- and beta-blocking actions of orally administered labetalol HCl contribute to a decrease in blood pressure in hypertensive patients. Labetalol HCl consistently, in dose-related fashion, blunted increases in exercise-induced blood pressure and heart rate, and in their double product. The pulmonary circulation during exercise was not affected by labetalol HCl dosing. Labetalol may also be used for purposes not listed in this medication guide. Sympathetic stimulation is a vital component supporting circulatory function in congestive heart failure. Beta-blockade carries a potential hazard of further depressing myocardial contractility and precipitating more severe failure. Although beta-blockers should be avoided in overt congestive heart failure, if necessary, labetalol HCl can be used with caution in patients with a history of heart failure who are well compensated. Caution should be exercised when labetalol hydrochloride injection is administered to a nursing woman. Cardiac Failure: Sympathetic stimulation is a vital component supporting circulatory function in congestive heart failure. Beta-blockade carries a potential hazard of further depressing myocardial contractility and precipitating more severe failure. Although beta-blockers should be avoided in overt congestive heart failure, if necessary, labetalol HCl can be used with caution in patients with a history of heart failure who are well compensated. Congestive heart failure has been observed in patients receiving labetalol HCl. Labetalol HCl does not abolish the inotropic action of digitalis on heart muscle. Exacerbation of Ischemic Heart Disease Following Abrupt Withdrawal: Angina pectoris has not been reported upon labetalol HCl discontinuation. However, hypersensitivity to catecholamines has been observed in patients withdrawn from beta-blocker therapy; exacerbation of angina and, in some cases, myocardial infarction have occurred after abrupt discontinuation of such therapy. When discontinuing chronically administered labetalol HCl tablets, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, therapy with labetalol HCl tablets should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Other symptoms of a low blood sugar level, such as dizziness and sweating, are unaffected by this drug. This product may also make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Symptomatic postural hypotension incidence, 58% is likely to occur if patients are tilted or allowed to assume the upright position within 3 hours of receiving labetalol hydrochloride injection. Therefore, the patient's ability to tolerate an upright position should be established before permitting any ambulation. Although beta-adrenergic receptor blockade is useful in the treatment of angina and hypertension, there are also situations in which sympathetic stimulation is vital. For example, in patients with severely damaged hearts, adequate ventricular function may depend on sympathetic drive. Beta-adrenergic blockade may worsen A-V block by preventing the necessary facilitating effects of sympathetic activity on conduction. Beta 2-adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm, and it may also interfere with exogenous bronchodilators in such patients. The amount of alpha to beta blockade depends on whether labetalol is administered orally or IV. sopp.info trileptal
This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use. For some folks, an operation to remove the tumor cures the disease. If the cancer does return, your doctor has other methods you can try that keep it in check. Patients should always be kept in a supine position during the period of intravenous drug administration. A substantial fall in blood pressure on standing should be expected in these patients. The patient's ability to tolerate an upright position should be established before permitting any ambulation, such as using toilet facilities. There are no adequate and well-controlled studies in pregnant women. Labetalol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Labetalol is highly selective for alpha1- adrenergic, and non-selective for beta-adrenergic receptors. It is about equipotent in blocking both beta1- and beta2- receptors. Care should be taken if labetalol is used concomitantly with calcium channel antagonists of the verapamil type. price pyrantel at cvs
Should side effects principally nausea or dizziness occur with these doses administered twice daily, the same total daily dose administered three times daily may improve tolerability and facilitate further titration. Titration increments should not exceed 200 mg twice daily. Nausea in 13, vomiting in 4, dyspepsia and taste distortion in 1 each. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Riva E, Mennini T, Latini R December 1991. The peripheral vascular resistance decreases when labetalol is first administered. Continuous labetalol use further decreases peripheral vascular resistance. Cimetidine has been shown to increase the bioavailability of labetalol HCl administered orally. Since this could be explained either by enhanced absorption or by an alteration of hepatic metabolism of labetalol HCl, special care should be used in establishing the dose required for blood pressure control in such patients. The dosage of labetalol hydrochloride tablets used in the hospital may be increased at 1-day intervals to achieve the desired blood pressure reduction. Patients should always be kept in a supine position during the period of IV drug administration. A substantial fall in blood pressure on standing should be expected in these patients. What happens if I overdose Trandate? It's not clear why some people get these tumors. Labetalol HCl given to pregnant women with hypertension did not appear to affect the usual course of labor and delivery. HCl has been injected. cost tenormin yahoo
There is pharmacologic evidence that norepinephrine may be the drug of choice. DOSAGE MUST BE INDIVIDUALIZED. The recommended initial dose is 100 mg twice daily whether used alone or added to a diuretic regimen. The usual maintenance dosage of labetalol HCl is between 200 and 400 mg twice daily. Robertson, D; Biaggioni, I 2012. Labetalol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Katzung, Bertram G. 2006. Basic and clinical pharmacology. New York: McGraw-Hill Medical. Since some elderly patients eliminate labetalol more slowly, however, adequate control of blood pressure may be achieved at a lower maintenance dosage compared to the general population. Cardiovascular: Intensification of A-V block see CONTRAINDICATIONS. IV push over 2 minutes.
Intravenous labetalol HCl has been shown to be effective in lowering blood pressure and relieving symptoms in patients with pheochromocytoma; higher than usual doses may be required. However, paradoxical hypertensive responses have been reported in a few patients with this tumor; therefore, use caution when administering labetalol HCl to patients with pheochromocytoma. MRHD revealed no evidence of drug-related harm to the fetus. There are no adequate and well-controlled studies in pregnant women. Labetalol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. San Francisco: McGraw Hill Lange Medical. The blood pressure should be monitored during and after completion of the infusion or IV injection. Rapid or excessive falls in either systolic or diastolic blood pressure during IV treatment should be avoided. In patients with excessive systolic hypertension, the decrease in systolic pressure should be used as an indicator of effectiveness in addition to the response of the diastolic pressure. The incidence of adverse reactions depends upon the dose of labetalol HCl. The largest experience is with oral labetalol HCl see labetalol HCl tablet product information for details. Whether you will be able to withstand a surgery or procedure. Immediately before the injection and at 5 and 10 minutes after injection, supine blood pressure should be measured to evaluate response. Additional injections of 40 or 80 mg can be given at 10-minute intervals until a desired supine blood pressure is achieved or a total of 300 mg of labetalol HCl has been injected. Does labetalol oral have side effects? Alternatively, add 40 mL of Labetalol hydrochloride injection to 250 mL of a commonly used intravenous fluid. Br J Clin Pharmacol. HCl tablets due to one or more adverse effects was required in 7% of all patients. In these same trials, other agents with solely beta-blocking activity used in the control groups led to discontinuation in 8% to 10% of patients, and a centrally acting alpha-agonist in 30% of patients. As with all drugs with beta-blocking activity, certain advice to patients being treated with labetalol HCl is warranted. While no incident of the abrupt withdrawal phenomenon exacerbation of angina pectoris has been reported with labetalol HCl, dosing with labetalol hydrochloride tablets should not be interrupted or discontinued without a physician's advice. Labetalol has been shown to cross the placental barrier in humans. Only negligible amounts of the drug crossed the blood-brain barrier in animal studies. Labetalol is approximately 50% protein bound. Central Nervous System: Reversible mental depression progressing to catatonia, an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on psychometrics. remeron online bestellen rezeptfrei
Seems like I have every side effect makes me wonder. I just do NOT want to take any more of these crAZY meds. you know because they the DR. just wants to put you on more meds. well no thank you! What is the most important information I should know about labetalol Trandate? Labetalol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. This drug may rarely cause serious rarely fatal liver disease. This can help you by replacing the nicotine in cigarettes. IV administration, respectively. Beta 2-agonist activity has been demonstrated in animals with minimal beta 1-agonist ISA activity detected. In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane stabilizing effect has been demonstrated. The minimum requirement for is a primary or secondary amine separated from a substituted benzene ring by one or two carbons. This configuration results in strong agonist activity. As the size of the substituent attached to the amine becomes greater, particularly with respect to a t-butyl group, then the molecule typically is found to have without intrinsic activity, and is, therefore, an antagonist. Labetalol, with its 1-methyl-3-phenylpropyl substituted amine, is greater in size relative to a t-butyl group and therefore acts predominantly as an antagonist. The overall structure of labetalol is very polar. This was created by substituting the isopropyl group in the standard beta-blocker structure with an aralkyl group, including a carboxamide group on the meta position, and by adding a hydroxyl group on the para position. You have two adrenal glands, one on top of each kidney, and you could get a tumor in one or both of them. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Since the half-life of labetalol is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period. The infusion should be continued until a satisfactory response is obtained and should then be stopped and oral labetalol HCl started see below. The effective intravenous dose is usually in the range of 50 to 200 mg. A total dose of up to 300 mg may be required in some patients. Doses of labetalol HCl that controlled hypertension did not affect renal function in mildly to severely hypertensive patients with normal renal function. Store at room temperature away from moisture and heat. When transferring patients from other antihypertensive drugs, Labetalol Hydrochloride Tablets should be introduced as recommended and the dosage of the existing therapy progressively decreased. purchase now daflon usa
Protect syringe from light. Congestive heart failure has been observed in patients receiving labetalol HCl. Labetalol HCl does not abolish the inotropic action of digitalis on heart muscle. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems such as a slow heartbeat, second- or third-degree atrioventricular block severe heart failure, breathing problems such as asthma, chronic bronchitis, emphysema. Drummer, O. H. 1984-01-01. "Pharmacology of combined alpha-beta-blockade. I". Drugs. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. aleve
Labetalol hydrochloride injection is prepared for continuous IV infusion by diluting the vial contents with commonly used IV fluids see below. This is especially important with labile diabetics. Beta-blockade also reduces the release of insulin in response to hyperglycemia; it may therefore be necessary to adjust the dose of antidiabetic drugs. Some smokers are unsuccessful the first time they try to quit. You may need to stop using this product and try again later. Many people who cannot quit the first time are successful the next time. If any of these side effects persist or worsen, stop using this and tell your doctor or promptly. FDA pregnancy category C. It is not known whether labetalol will harm an unborn baby. Labetalol may cause heart or lung problems in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. As in the general population, some elderly patients 60 years of age and older have experienced orthostatic hypotension, dizziness, or lightheadedness during treatment with labetalol. Because elderly patients are generally more likely than younger patients to experience orthostatic symptoms, they should be cautioned about the possibility of such side effects during treatment with labetalol. Pediatric: No studies have established safety or usefulness in this population. When labetalol is given in acute situations, it decreases the peripheral vascular resistance and systemic blood pressure while having little effect on the heart rate, cardiac output and stroke volume, despite its alpha1-, beta1- and beta2- blocking mechanism. These effects are mainly seen when the person is in the upright position. Caution must be observed when reducing severely elevated blood pressure. A number of adverse reactions, including cerebral infarction, optic nerve infarction, angina, and ischemic changes in the electrocardiogram, have been reported with other agents when severely elevated blood pressure was reduced over time courses of several hours to as long as 1 or 2 days. The desired blood pressure lowering should therefore be achieved over as long a period of time as is compatible with the patient's status. aleve
Labetalol is used with or without other medications to treat high blood pressure hypertension. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Two of these isomers, the S, S- and R, S- are inactive. The third, the S, R-isomer, is a powerful blocker. The fourth isomer, the R, R-isomer which is also known as dilevalol, is a mixed nonselective and selective blocker. Labetalol is typically given as a racemic mixture to achieve both alpha and beta receptor blocking activity. Pheochromocytoma: Labetalol HCl has been shown to be effective in lowering the blood pressure and relieving symptoms in patients with pheochromocytoma. However, paradoxical hypertensive responses have been reported in a few patients with this tumor; therefore, use caution when administering labetalol HCl to patients with pheochromocytoma. Subsequent oral dosing with labetalol tablets should begin when it has been established that the supine diastolic blood pressure has begun to rise. The recommended initial dose is 200 mg, followed in 6 to 12 hours by an additional dose of 200 or 400 mg, depending on the blood pressure response. Richards; J Tuckman; B N Prichard October 1976. Teratogenic studies were performed with labetalol in rats and rabbits at oral doses up to approximately six and four times the maximum recommended human dose MRHD respectively. No reproducible evidence of fetal malformations was observed. Increased fetal resorptions were seen in both species at doses approximating the MRHD. Labetalol hydrochloride injection is prepared for continuous intravenous infusion by diluting the drug with commonly used intravenous fluids see below. DOSAGE MUST BE INDIVIDUALIZED. The recommended dosage is 100 mg daily whether used alone or added to a diuretic regimen. Initiation of Dosing With labetalol hydrochloride Tablets: Subsequent oral dosing with labetalol hydrochloride Tablets should begin when it has been established that the supine diastolic blood pressure has begun to rise. The recommended initial dose is 200 mg, followed in 6 to 12 hours by an additional dose of 200 or 400 mg, depending on the blood pressure response. BEFORE ACCESSING OR USING THIS SITE. Overdosage with labetalol HCl causes excessive hypotension that is posture sensitive and, sometimes, excessive bradycardia. Patients should be placed supine and their legs raised if necessary to improve the blood supply to the brain. If overdosage with labetalol HCl follows oral ingestion, gastric lavage or pharmacologically induced emesis using syrup of ipecac may be useful for removal of the drug shortly after ingestion.
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For subsequent outpatient titration or maintenance dosing see Labetalol Hydrochloride Tablets Product Information DOSAGE AND ADMINISTRATION for additional recommendations. Beta-blockers may decrease the rate at which aneurysms grow. In general, the risks of surgery to repair smaller aneurysms outweigh the possible benefits, because smaller aneurysms rarely rupture. Your blood pressure will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly. Blood and urine tests. They check for signs that you make too many sex hormones or steroids, such as low levels of potassium or high levels of cortisol or estrogen.
Labetalol hydrochloride injection was NOT compatible with 5% Sodium Bicarbonate Injection, USP. Care should be taken when administering alkaline drugs, including furosemide, in combination with labetalol. Compatibility should be assured prior to administering these drugs together. The metabolism of labetalol is mainly through conjugation to glucuronide metabolites. The metabolites are present in plasma and are excreted in the urine and, via the bile, into the feces. Approximately 55% to 60% of a dose appears in the urine as conjugates or unchanged labetalol within the first 24 hours of dosing. The dosage of labetalol tablets used in the hospital may be increased at 1-day intervals to achieve the desired blood pressure reduction.
The best dose for you is the dose that decreases the urge to smoke without side effects from too much nicotine. Your dose will need to be adjusted to your needs, including history and medical condition. During the first 6 weeks, use 1 lozenge every 1-2 hours at least 9 lozenges a day. HCl and a molecular weight of 364. Your tumor can change your levels of some hormones, which sets off a variety of symptoms. For instance, high levels of male hormones, called androgens, can cause too much face or body hair to grow. They can also enlarge the penis in young boys or the clitoris in girls. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company.
Hepatic necrosis, hepatitis, cholestatic jaundice, elevated liver function tests. Do not share this medication with others. What is labetalol Trandate?